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KMID : 1134820000290030485
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Journal of the Korean Society of Food Science and Nutrition
2000 Volume.29 No. 3 p.485 ~ p.492
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Toxic Effects of the Megadose Garlic Juice in the Rats
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Seo Hwa-Jung
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Abstract
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In the present study toxic effects of megadose of dietary garlic were investigated in an experimental model consisted of 3 groups of Wistar rats : group CO received a basal diet. The diets were supplemented 3% (or 3.6g/kg.body wt.day)raw garlic (as juice) for group G3 and 5% (or 6.0g/kg. body wt. day) raw garlic for group G5 respectively and fed to rats over one month period of experimental time. There were no abnormality or apparent changes in the appearance and motility in all experimental groups. But some rats in group G3 and large parts of group G5 showed mild erythema on their mucosal membrane of stomach. The his- topathological changes were observed in the microscopic examination of 3 rats liver specimen of group G3 and 7 rats liver specimen of group G5. The histopathological signs were mainly consisted of degenerative change in hepatic parenchyme and inflammatory cells infiltration in portal tract in group G3 rats, and dense inflammatory cell infiltration in hepatic parenchyme with mild congestion and slight necrosis of interlobular hepatocyte in group G5. The large dose of dietary garlic up to 5% did not have any significant adverse effects on the body weight gain of rats. But the specific activites of GOT, GPT and alkaline phosphatase, and BUN levels in the serum of group G3 and G5 were significantly increased in dose dependent fashion as compared to control group. Total-cholesterol and hemoglobin levels were not affected by the administration of megadose of garlic. The results showed that large dose of dietary raw garlic with 3～5% had some toxic effects in rats.
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KEYWORD
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toxic effects, mega dose garlic, rats
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